1-Dodecylimidazole

SKU: orb1303746

Description

1-Dodecylimidazole is a lysosomotropic detergent and cytotoxic agent that induces cell death via lysosomal membrane permeabilization. It also demonstrates hypocholesterolemic and broad-spectrum antifungal properties. This small molecule is used in research areas including cell death mechanisms, lysosome biology, and antifungal studies in both in vitro and in vivo models.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	4303-67-7
MW	236.4
Purity	99.09% (May vary between batches)
Formula	C₁₅H₂₈N₂
SMILES	CCCCCCCCCCCCn1ccnc1
Target	Antifungal
Solubility	10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (13.96 mM);DMSO:100 mg/mL (423.01 mM)

Bioactivity

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In Vivo	The hypocholesterolaemic activity of 1-dodecylimidazole partly arises from inhibiting cholesterol biosynthesis at the 2,3-oxidosqualene sterol cyclase level. Administration of 1-dodecylimidazole (150 mg/kg body wt; by stomach tube; daily for 10 days) results in lower serum cholesterol concentrations compared to control rats. Read more...
In Vitro	1-Dodecylimidazole is an acid-activated detergent with a pKa of 6.3 which has been shown to be cytotoxic to cells in culture. 1-Dodecylimidazole displayed extracellular pH (pHe)-dependent cytotoxicity against EMT-6 and MGH U1 cells. cell killing was dose-dependent and was 100-fold greater at pHe 6.0 than pHe 7.0. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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tumors, properties, Inhibitor, extracellular, Fungal, N-Dodecylimidazole, inhibit, Antifungal, acidic, 1 Dodecylimidazole, 1Dodecylimidazole, 1-Dodecylimidazole, detergent, conditions

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Compound Identifiers

PubChem CID

78002 ↗

Key Properties

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No computed properties available.

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