17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic Acid

SKU: orb1984945

Description

17-oxo-4(Z),7(Z),10(Z),13(Z),15(E),19(Z)-Docosahexaenoic acid is a metabolite of lipoxygenase-mediated oxidation of DHA that is produced endogenously by aspirin-enhanced COX-2 activity. It has been shown to activate Nrf2-dependent antioxidant gene expression, to act as a PPARγ agonist (EC50 = ~200 nM), and to inhibit pro-inflammatory cytokine and nitric oxide production at biological concentration ranges (5-25 μM).

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Key Properties

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CAS Number	1233715-28-0
MW	342.479
Formula	C₂₂H₃₀O₃
SMILES	CC\C=C/CC(=O)\C=C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O
Target	PPAR,Others,Nrf2

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

PPAR,Others,Nrf2

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