2-Guanidinobezimidazole

SKU: orb3028361

Description

2-Guanidinobenzimidazole (2GBI) is a selective agonist of NLRP3, with a KD value of 1.29 μM for His-GFP-NLRP3. It directly binds to the LRR domain of NLRP3, facilitating the assembly and activation of the inflammasome. Additionally, 2-Guanidinobenzimidazole enhances antitumor immunity, inhibits tumor growth, and overcomes resistance to immune checkpoint blockade (ICB).

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Key Properties

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CAS Number	5418-95-1
MW	175.191
Formula	C₈H₉N₅
SMILES	N=C(N)NC1=NC=2C=CC=CC2N1
Target	NOD-like Receptor (NLR)

Storage & Handling

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Storage	-20°C
Disclaimer	For research use only

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Gene Symbol

NOD-like Receptor (NLR)

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