3-Methoxysalicylaldehyde

SKU: orb1218777

Description

3-Methoxysalicylaldehyde is a natural product.

Images & Validation

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Key Properties

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CAS Number	148-53-8
MW	152.15
Purity	>98% (HPLC)
Formula	C₈H₈O₃
SMILES	COc1cccc(C=O)c1O
Target	Others
Solubility	In Vitro: DMSO : 100 mg/mL (657.25 mM)

Bioactivity

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In Vivo

o-Vanillin (2-Vanillin; 60 mg/kg; p.o. ; daily, for 5 d) inhibits tumor growth in mice bearing A375 human melanoma xenografts. Animal model: Male NSG mice with A375 human melanoma xenografts (12-16 weeks of age). Dosage: 60 mg/kg. Administration: Oral administration; daily, for 5 days. Result: Delayed the growth of A375 human melanoma xenografts in immunodeficient NSG mice.

In Vitro

o-Vanillin (2-Vanillin; 0-125 μg/mL; 24-72 h) inhibits the mycelial growth of A. flavus in a dose-dependent manner. o-Vanillin (0-100 μg/mL; 48 h; A. flavus) changes the morphology of mycelia and induces irregular shrinkage of the mycelia. o-Vanillin (0-100 μg/mL; A. flavus) decreases the protein content of the cell wall surface and the content of β-1, 3-glucan. o-Vanillin (0-100 μg/mL; A. flavus) destroys cell membrane integrity. o-Vanillin releases cell constituents and decreases extracellular pH value. o-Vanillin (0-100 μg/mL) could effectively inhibit the growth of A. flavus on corn kernels. o-Vanillin (0-250 μM) inhibits doxorubicin-mediated induction of NF B activity by 65% in A375/NF B-Luc cells. o-Vanillin suppresses 4-HC-induced activity by 43%.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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