3,4-Dimethoxycinnamic acid

SKU: orb1221608

Description

3, 4-Dimethoxycinnamic acid, previously identified in plasma after coffee consumption, was rapidly absorbed in the free form most likely by passive diffusion in the upper gastrointestinal tract.

Images & Validation

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Key Properties

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CAS Number	2316-26-9
MW	208.21
Purity	>98% (HPLC)
Formula	C₁₁H₁₂O₄
SMILES	COC1=C(C=C(C=C1)/C=C/C(=O)O)OC
Target	Others
Solubility	In Vitro: DMSO : 50 mg/mL (240.14 mM)

Bioactivity

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In Vitro

3, 4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 μM) attenuates the ethanol-induced apoptosis of ethanolexposed L-02 cells. 3, 4-Dimethoxycinnamic acid (25, 50 and 100 μM) inhibits the expression levels of Nox4 and p22phox in L-02 cells. 3, 4-Dimethoxycinnamic acid (25, 50 and 100 μM) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells.3, 4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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O-Methylferulic acid

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