4-methoxylonchocarpin

SKU: orb1737436

Description

4-Methoxylonchocarpin is a natural compound isolated from Abrus precatorius roots, demonstrating potent anti-inflammatory activity. It functions by inhibiting LPS binding to TLR4 in macrophages, thereby suppressing NF-κB-mediated TNF-α expression, and has shown efficacy in a murine TNBS-induced colitis model. This makes it a valuable small molecule for researching TLR4/NF-κB signaling in inflammatory diseases.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	51589-67-4
MW	336.38
Purity	98.67%
Formula	C₂₁H₂₀O₄
SMILES	OC1=C2C(OC(C)(C)C=C2)=CC=C1C(/C=C/C3=CC=C(OC)C=C3)=O
Target	TLR,Interleukin,TNF,NF-κB

Bioactivity

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In Vivo

Oral administration of 4-methoxylonchocarpin (ML) in mice with TNBS-induced colitis suppressed colon shortening and colonic myeloperoxidase activity. ML treatment significantly inhibited the activation of nuclear factor (NF)-κB and phosphorylation of transforming growth factor β-activated kinase 1 in the colon. Treatment with ML also inhibited TNBS-induced expression of IL-1β, IL-17A, and TNF. While ML reduced the TNBS-induced expression of M1 macrophage markers such as arginase-2 and TNF, it was found to increase the expression of M2 macrophage markers such as arginase-1 and IL-10. In conclusion, oral administration of ML attenuated colitis in mice by inhibiting the binding of LPS to TLR4 on immune cells and increasing the polarization of M1 macrophages to M2 macrophages.

Storage & Handling

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Storage	store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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NF-kB, NFkB, NF-κB, NFκB, TNF

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Compound Identifiers

PubChem CID

10472189 ↗

Key Properties

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No computed properties available.

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