4'-O-Methylbavachalcone

SKU: orb1303439

Description

4'-O-Methylbavachalcone is a natural compound derived from Psoralea corylifolia. It acts as an inhibitor of the SARS-CoV papain-like protease (PLpro), demonstrating an IC50 value of 10.1 µM in enzymatic assays, making it a candidate for antiviral research targeting coronavirus replication mechanisms.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	20784-60-5
MW	338.4
Purity	99.92%
Formula	C₂₁H₂₂O₄
SMILES	COc1cc(O)c(cc1CC=C(C)C)C(=O)\C=C\c1ccc(O)cc1
Target	SARS-CoV
Solubility	DMSO:30 mg/mL (88.65 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.91 mM)

Bioactivity

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Target IC50	Plpro:10.1 μM

Storage & Handling

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Storage	keep away from direct sunlight \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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4'OMethylbavachalcone, 4'-O-Methylbavachalcone, 4' O Methylbavachalcone, Inhibitor, inhibit, papain-like protease (PLpro), O-Methylbroussochalcone B, SARSCoV, SARS coronavirus, SARS-CoV

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Compound Identifiers

PubChem CID

5321765 ↗

Key Properties

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No computed properties available.

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