4-Octyl itaconate

SKU: orb1302740

Description

4-Octyl Itaconate is a cell-permeable anti-inflammatory metabolite derivative. It functions by alkylating KEAP1 to activate the Nrf2 pathway and inhibiting STING phosphorylation. This compound is widely used in research to study inflammation, oxidative stress, and innate immunity in both cellular and animal models.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	3133-16-2
MW	242.31
Purity	99.94% (May vary between batches)
Formula	C₁₃H₂₂O₄
SMILES	C(CC(C(O)=O)=C)(OCCCCCCCC)=O
Target	Nrf2
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:12.2 mg/mL (50.35 mM);DMSO:237.5 mg/mL (980.15 mM)

Bioactivity

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In Vivo

METHODS: To test the anti-inflammatory activity in vivo, 4-Octyl Itaconate (50 mg/kg in 40% cyclodextrin in PBS) was intraperitoneally injected into mice, and 2 h later LPS (2.5 mg/kg) was intraperitoneally injected. RESULTS: 4-Octyl Itaconate counteracted the pro-inflammatory response to LPS in vivo. 4-Octyl Itaconate activated Nrf2, prolonged survival, decreased clinical scores and improved thermoregulation, and decreased IL-1β and TNF levels, but not IL-10, in the LPS model of sepsis. METHODS: To investigate the role in immunosuppressive impairment in sepsis, 4-Octyl Itaconate (25-50 mg/kg) was injected intraperitoneally into a C57bl/6 mouse model of sepsis established by cecum ligation and puncture (CLP). RESULTS: 4-Octyl Itaconate inhibits the early release of inflammatory and oxidative stress-related factors to reduce tissue and organ damage in septic mice.

Storage & Handling

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Storage	keep away from direct sunlight,store under nitrogen,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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4 Octyl itaconate, 4Octyl itaconate, 4-Octyl itaconate, 4-Octyl Itaconate, inhibit, Keap1-Nrf2, Inhibitor

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Compound Identifiers

PubChem CID

14239884 ↗

Key Properties

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No computed properties available.

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