6-Hydroxyflavanone

SKU: orb1684824

Description

6-Hydroxyflavanone, a natural compound from Acorus calamus, acts as a multi-target agent against COX-2, 5-LOX, and opioid/GABA-A receptors. It demonstrates anti-inflammatory and analgesic effects, validated in a streptozotocin-induced diabetic neuropathy model, making it a useful research tool for studying neuropathic pain mechanisms.

Research Area

Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	4250-77-5
MW	240.25
Purity	99.85%
Formula	C₁₅H₁₂O₃
SMILES	Oc1ccc2OC(CC(=O)c2c1)c1ccccc1
Target	Opioid Receptor,COX,Lipoxygenase,GABA Receptor
Solubility	DMSO:2.41 mg/mL (10.03 mM)

Bioactivity

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Target IC50

Androgen receptor:3.3 µM

In Vivo

6-Hydroxyflavanone (6-HF) (6-HF) (5, 30, and 60 mg/kg ) inhibited the COX-2 and 5-LOX enzymes significantly. It substantially reduced heat nociception in a hot plate analgesia meter, as well as carrageenan-induced paw edema in rodent models. The authors discovered that 6-HF exhibited anti-nociception properties in a streptozotocin-induced diabetic neuropathy (DIN) model. According to the findings of this study, 6-HF demonstrated the ability to diminish inflammation caused by diabetes, as well as to exert an anti-nociceptive.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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GABAA, GABA Receptor, GABAReceptor, 5-LOX, 6 Hydroxyflavanone, 6Hydroxyflavanone, 6-Hydroxyflavanone, COX-2

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Compound Identifiers

PubChem CID

2734580 ↗

Key Properties

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No computed properties available.

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