7-Methoxyflavone

SKU: orb1299394

Description

This small molecule, 7-Methoxyflavone, is a natural compound isolated from Zornia brasiliensis. It exhibits antinociceptive properties, making it a useful research tool for studying pain mechanisms in both in vitro and in vivo models of nociception.

Research Area

Metabolism Research

Images & Validation

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Key Properties

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CAS Number	22395-22-8
MW	252.26
Purity	99.51%
Formula	C₁₆H₁₂O₃
SMILES	COc1ccc2c(c1)oc(cc2=O)-c1ccccc1
Target	Cytochromes P450,Others
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.93 mM);DMSO:25 mg/mL (99.1 mM)

Bioactivity

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In Vivo

The antinociceptive effect of 7-methoxyflavone (7MF) in mice using the following tests: acetic acid-induced writhing, glutamate- and formalin-induced nociception and hotplate. 7MF (30, 50, 100 and 300 μmol/kg, i.p.) reduced the number of writhes, with ID = 82.5 ± 11.7 μmol/kg and E max = 58.4%. 7MF treatment (100 μmol/kg, i.p.) inhibited paw-licking time in the neurogenic phase of the formalin pain response (65.6%) and did not decrease the nociceptive response in the inflammatory phase. In addition, in glutamate-induced nociception, 7MF inhibited 26% of the nociceptive answer. On the other hand, 7MF did not increase the latency time of the animals in the hotplate test. These results suggest that 7MF has peripheral antinociceptive activity

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Inhibitor, inflammatory, inhibit, paw-licking time, 7Methoxyflavone, 7-Methoxyflavone, 7 Methoxyflavone, peripheral antinociceptive

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Compound Identifiers

PubChem CID

466268 ↗

Key Properties

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No computed properties available.

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