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7-Methylguanine

SKU: orb1909587

Description

7-Methylguanine is a natural metabolite and competitive PARP1 inhibitor (Ki=61 μM) that disrupts NAD+ binding. It exhibits anticancer properties in research models and serves as a chemical probe for studying protein-DNA interactions in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin, Metabolism Research, Molecular Biology

Images & Validation

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7-Methylguanine

Key Properties

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CAS Number578-76-7
MW165.15
Purity99.99% (May vary between batches)
FormulaC6H7N5O
SMILESO=C1N=C(N)NC=2N=CN(C12)C
TargetPARP,Endogenous Metabolite
Solubility1M NaOH:80 mg/mL (484.41 mM);H2O:3.3 mg/mL (19.98 mM)

Bioactivity

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Target IC50
PARP-1:61 μM (Ki)
In Vivo
In CBA, BALB/c, and C57BL/6 mice, 7-Methylguanine (50 mg/kg, administered orally, three times per week for 4 weeks) did not cause adverse reactions or morphological changes, while it inhibited tumor growth in CBA mice with uterine sarcoma US-322 . In BALB/c mice transplanted with Akatol tumors, 7-Methylguanine (50 mg/kg, administered via gavage, three times per week) effectively penetrated tumor tissues and suppressed the growth of colon adenocarcinoma .
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In Vitro
7-Methylguanine (0-200 μM) inhibits the activity of PARP1 enzyme in a dose-dependent manner . 7-Methylguanine is a competitive PARP-1 inhibitor with an inhibition constant (Ki value) of 61 μM . 7-Methylguanine (0-450 μM) suppresses the catalytic activity of PARP-1, thereby preventing the dissociation of the PARP-1-DNA complex . After 24 hours of treatment with 7-Methylguanine (0.02-0.2 mg/mL), no DNA damage was observed in immortalized Homo sapiens renal epithelial cells (NKE-hTERT) .
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Storage & Handling

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Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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7Methylguanine, 7-Methylguanine, 7 Methylguanine, Human Endogenous Metabolite, N7-Methylguanine

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Compound Identifiers

PubChem CID
135398679 ↗

Key Properties

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No computed properties available.

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7-Methylguanine (orb1909587)

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25 mg
$ 70.00
50 mg
$ 80.00
100 mg
$ 100.00
500 mg
$ 180.00
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