Cart summary

You have no items in your shopping cart.

A-366

SKU: orb1303986

Description

A-366

Research Area

Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number1527503-11-2
MW329.44
Purity98.15%
FormulaC19H27N3O2
SMILESCOc1cc2c(cc1OCCCN1CCCC1)N=C(N)C21CCC1
TargetEpigenetic Reader Domain,Histone Methyltransferase
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.07 mM);DMSO:32.9 mg/mL (99.87 mM)

Bioactivity

Target IC50
G9a/GLP:3.3 nM
In Vivo
For tumor cell growth, A-366 had less toxic effects than some other G9a/GLP small molecule compound inhibitors, and no difference in the methylation effect on H3K9me2. Various leukemia cell lines were treated with A-366 in vitro, and these tumor cells would produce significant differentiation and morphological changes.
In Vitro
For tumor cell growth, A-366 had less toxic effects than some other G9a/GLP small molecule compound inhibitors, and no difference in the methylation effect on H3K9me2. Various leukemia cell lines were treated with A-366 in vitro, and these tumor cells would produce significant differentiation and morphological changes.
Cell Research
PC-3 prostate adenocarcinoma cells are incubated in triplicate with DMSO or the indicated concentrations of A-366 or UNC0638 for 72 hours. H3K9me2 levels are assessed by In-Cell Western assay. (Only for Reference)

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

cells, A366, A-366, A 366, inhibit, methyltransferase, H3K4me3, G9a/GLP, Epigenetic Reader Domain, EpigeneticReaderDomain, epigenetics, HistoneMethyltransferase, Histone Methyltransferase, Inhibitor, interaction, selective, peptide-competitive

Similar Products

  • A-366 [orb1226148]

    >98% (HPLC)

    1527503-11-2

    329.4366

    C19H27N3O2

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 2 mg, 1 g, 500 mg, 200 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

A-366 (orb1303986)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 70.00
2 mg
$ 90.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 140.00
25 mg
$ 260.00
50 mg
$ 420.00
100 mg
$ 660.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry