A-674563 2HCl(552325-73-2(fb-2hcl))

SKU: orb1301041

Description

A-674563 2HCl is a potent and selective Akt1 inhibitor with a Ki of 11 nM. It exhibits modest activity against PKA and over 30-fold selectivity versus PKC. This tool compound is used in vitro and in vivo to study the PI3K/Akt signaling pathway in cancer and metabolic research.

Research Area

Cell Biology, Epigenetics & Chromatin, Signal Transduction

Images & Validation

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Key Properties

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Target	CDK,PKA,Akt,PKC,ERK
Molecular Weight	431.36
Purity	99.57% (May vary between batches)
Formula	C₂₂H₂₄Cl₂N₄O
SMILES	Cl.Cl.Cc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccccc2)c1

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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CDK2, A-674563 2HCl(552325-73-2(fb-2hcl)), A674563 2HCl(552325732(fb2hcl)), A 674563 2HCl(552325 73 2(fb 2hcl)), Akt1, ERK2, PKA, PKCδ

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Compound Identifiers

PubChem CID

155977517 ↗

Key Properties

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No computed properties available.

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