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A-77636

SKU: orb1944491

Description

A-77636 is a potent, selective, and long-acting oral dopamine D1 receptor agonist with an effective concentration (EC50) of 1.1 nM and a corresponding pEC50 value of 8.13. It demonstrates the highest affinity for the dopamine D1 receptor with a dissociation constant (Ki) of 39.8 nM and a pKi of 7.40 ± 0.09. Notably, A-77636 exhibits antiparkinsonian activity.

Images & Validation

Key Properties

CAS Number778546-51-3
MW329.43
FormulaC20H27NO3
SMILESC(N)[C@@H]1O[C@H]([C@]23CC4(CC(C2)(CC(C3)(C4)[H])[H])[H])CC=5C1=CC=C(O)C5O
TargetDopamine Receptor

Storage & Handling

Storage-20°C
DisclaimerFor research use only

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A-77636 (orb1944491)

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