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AC-186

SKU: orb1701273

Description

AC-186 is a selective nonsteroidal agonist for estrogen receptor β (ERβ), exhibiting high affinity for ERβ (EC50 = 6 nM) over ERα (EC50 = 5000 nM). Its neuroprotective properties have been demonstrated in research models, supporting its use in studying neurodegenerative conditions such as Parkinson's disease.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number1421854-16-1
MW306.32
Purity99.53% (May vary between batches)
FormulaC18H17F3O
SMILESFC=1C=CC=CC1C2(C3=CC=C(O)C=C3)CCC(F)(F)CC2
TargetEstrogen/progestogen Receptor,Estrogen Receptor/ERR
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.77 mM);DMSO:80 mg/mL (261.16 mM)

Bioactivity

Target IC50
ERβ:6 nM (EC50)|ERα:5000 nM (EC50)
In Vivo
In male Sprague-Dawley rats weighing 225-250 g, AC-186 (10 mg/kg; s.c.; once) prevented motor, cognitive, and sensorimotor gating deficits and mitigated the loss of dopamine neurons in the substantia nigra, but had no effect in females.
In Vitro
In LNCaP cells, AC-186 (10 μM; 72 hours) inhibits the growth of LNCaP cells.

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AC186, AC-186, AC 186, ER, Estrogen Receptor, EstrogenReceptor, progestogen Receptor, progestogenReceptor
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

AC-186 (orb1701273)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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1 mg
$ 90.00
5 mg
$ 150.00
1 ml x 10 mM (in DMSO)
$ 170.00
10 mg
$ 200.00
25 mg
$ 330.00
50 mg
$ 480.00
100 mg
$ 700.00
200 mg
$ 960.00
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