AC-340

AC-340 is a potent hybrid molecule functioning as a VDR agonist and HDAC inhibitor. It can significantly induce the expression of VDR target genes such as CYP24A1, with a selectivity for HDAC2 approximately 10 times greater than for HDAC6 (IC50= 0.37 μM). By causing extensive protein hyperacetylation, such as that of tubulin and H3K9/K27, AC-340 enhances VDR superagonism, resulting in increased acetylation levels of H3K27 on VDR target genes. AC-340 is applicable in research related to melanoma.