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Ac4GlcNAz

SKU: orb2944349

Description

Ac4GlcNAz is a cell-permeable metabolic chemical reporter for GlcNAc, enabling the visualization of glycosylation via bioorthogonal click chemistry with fluorescent probes. It is widely used for in vivo and in vitro labeling of O-GlcNAc and other glycans in cell biology and glycoproteomics research.

Images & Validation

Key Properties

CAS Number98924-81-3
MW430.37
Purity99.93%
FormulaC16H22N4O10
SMILESO(C(C)=O)[C@@H]1[C@@H](NC(CN=[N+]=[N-])=O)C(OC(C)=O)O[C@H](COC(C)=O)[C@H]1OC(C)=O
TargetOthers
SolubilityDMSO:80 mg/mL (185.89 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (7.67 mM)

Bioactivity

In Vitro
Ac4GlcNAz is a chemical probe for metabolic O-GlcNAc labeling. In mammalian cells (e.g., PC-3, HeLa, HEK293), Ac4GlcNAz efficiently taken up and converted into UDP-GlcNAz, which is incorporated into proteins by OGT. At 100 μM for 24 hours, labeling is efficient and time- and dose-dependent, as shown by CuAAC detection. however, due to its per-O-acetylated structure, Ac4GlcNAz also causes undesired S-glyco modification on cysteine residue.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
DisclaimerFor research use only

Alternative Names

N-azidoacetylglucosamine-tetraacylated

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Ac4GlcNAz (orb2944349)

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% DMSO +
%+
% Tween 80 +
%

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1 mg
$ 80.00
5 mg
$ 130.00
10 mg
$ 170.00
25 mg
$ 270.00
50 mg
$ 360.00
100 mg
$ 480.00
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