Ac4ManNAz

SKU: orb1308698

Description

Ac4ManNAz is a metabolic chemical reporter for glycoprotein labeling, enabling selective azide incorporation into cellular glycans. This tool facilitates cell tracking and proteomic analysis through bioorthogonal chemistry in both live-cell (in vitro) and animal (in vivo) studies.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	361154-30-5
MW	430.37
Purity	98.42%
Formula	C₁₆H₂₂N₄O₁₀
SMILES	O(C(C)=O)[C@@H]1[C@H](NC(CN=[N+]=[N-])=O)C(OC(C)=O)O[C@H](COC(C)=O)[C@H]1OC(C)=O
Target	PROTAC Linker
Solubility	DMSO:252.5 mg/mL (586.7 mM)

Bioactivity

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In Vitro

METHODS: A549 cells were cultured with 0, 10, and 50 μM Ac4ManNAz, and total RNA was extracted to evaluat the quantity and quality of total RNA. Results Compared with untreated A549 cells, mRNA expression levels changed 7-fold; biological functional pathways related to urogenital cancer and cell invasion were significantly activated, while signal transduction related to cell maturation and surface receptor ligation was inhibited. METHODS: Ac4MAnNAz (0 50 μM) treated A549 cells, and analyze the channel activation, proliferation ability and vitality of A549 cells treated with Ac4ManNAz; Ac4ManNAz (0, 10, 20, 50 μM, 30 hours) treated A549 cells, and performed wounds on A549 cells Healing and invasion assays. Results There was no significant change in the activities of TRP M7 and VSOR Cl channels, an the growth rate of A549 cells was reduced by 10%; a the concentration of Ac4ManNAz increased the migration and invasion abilities gradually decreased,

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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tracking, PROTAC Linker, PROTACLinker, Inhibitor, labeling, glycoprotein, inhibit, PEGs, azido, Ac4ManNAz, Ac-4ManNAz

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Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

71311757 ↗

Key Properties

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No computed properties available.

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Ac4ManNAz (orb1308698)

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Purity:	mass identification (ESI-MS)
CAS Number:	361154-30-5
MW:	Theoretical MW: 430.37 g/mol; Detected MW: 430.13 g/mol
Formula:	C₁₆H₂₂N₄O₁₀

Purity:	mass identification (ESI-MS)
CAS Number:	361154-30-5
MW:	Theoretical MW: 430.37 g/mol; Detected MW: 430.13 g/mol
Formula:	C₁₆H₂₂N₄O₁₀

Purity:	mass identification (ESI-MS)
CAS Number:	361154-30-5
MW:	Theoretical MW: 430.37 g/mol; Detected MW: 430.13 g/mol
Formula:	C₁₆H₂₂N₄O₁₀

Purity:	>98% (HPLC)
CAS Number:	361154-30-5
MW:	430.4
Formula:	C₁₆H₂₂N₄O₁₀

Ac4ManNAz

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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