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ACH-000143

SKU: orb1298295

Description

ACH-000143 is a novel small molecule agonist that selectively targets and activates melatonin receptors MT1 and MT2. It is a valuable research tool for investigating circadian rhythms, sleep disorders, and neuroprotection in both in vitro and in vivo experimental models.

Research Area

Cell Biology, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number2225836-30-4
MW297.74
Purity98.05% (May vary between batches)
FormulaC13H16ClN3O3
SMILESCOc1nc2cc(Cl)c(OC)cc2n1CCNC(C)=O
TargetMT Receptor,Melatonin Receptor
SolubilityDMSO:60 mg/mL (201.52 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.72 mM)

Bioactivity

Target IC50
MT1:0.06 nM(EC50)|MT2:0.32 nM(EC50)
In Vivo
Two-month oral administration of ACH-000143 in high-fat diet rats led to a reduction in body weight gain similar to dapagliflozin with superior results on hepatic steatosis and triglyceride levels.
In Vitro
ACH-000143 demonstrated subnanomolar potency at MT1/MT2 receptors, high oral bioavailability in rodents, peripherally preferred exposure, and excellent selectivity in a broad panel of targets.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ACH 000143, ACH000143, ACH-000143, Inhibitor, HFD, Melatonin Receptor, MelatoninReceptor, inhibit, MTReceptor, MT1 receptor, MT2 receptor, MT Receptor, low, obese, toxicity, steatosis

Similar Products

  • ACH-000143 [orb1218410]

    >98% (HPLC)

    2225836-30-4

    297.74

    C13H16ClN3O3

    5 mg, 25 mg, 50 mg, 10 mg, 1 g, 500 mg, 100 mg
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Key Properties

No computed properties available.

Protocol Information

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100 mg
$ 1,180.00
250 mg
$ 2,100.00
1 g
$ 4,220.00
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