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Acivicin hydrochloride

SKU: orb1980253

Description

Acivicin hydrochloride is the hydrochloride salt of the natural glutamine analog Acivicin. It acts as a potent inhibitor of γ-glutamyltransferase (GGT) and L-asparagine synthetase, blocking nucleotide biosynthesis. This cytotoxic mechanism has been investigated in vitro and in vivo for cancer research, particularly in studies targeting glutamine-dependent metabolic pathways.

Research Area

Infectious Disease & Virology, Metabolism Research

Images & Validation

Key Properties

CAS Number161922-40-3
MW215.04
Purity99.14% (May vary between batches)
FormulaC5H8Cl2N2O3
SMILES[C@H](C(O)=O)(N)[C@]1(ON=C(Cl)C1)[H].Cl
TargetTransferase,Parasite
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (15.35 mM);DMSO:80 mg/mL (372.02 mM)

Bioactivity

In Vitro
Methods: HepG2 cells were treated with Acivicin hydrochloride (0.1-50 μM, 5 days) and cell viability was measured. Results: Its IC50 value in HepG2 cells was 0.7 μM.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AT125 hydrochloride, AT-125 hydrochloride, U42126 hydrochloride, U-42126 hydrochloride
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Key Properties

No computed properties available.

Protocol Information

Available Sizes

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2 mg
$ 190.00
DispatchUsually dispatched within 5-10 working days
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