Acivicin hydrochloride

SKU: orb1980253

Description

Acivicin hydrochloride is the hydrochloride salt of the natural glutamine analog Acivicin. It acts as a potent inhibitor of γ-glutamyltransferase (GGT) and L-asparagine synthetase, blocking nucleotide biosynthesis. This cytotoxic mechanism has been investigated in vitro and in vivo for cancer research, particularly in studies targeting glutamine-dependent metabolic pathways.

Research Area

Infectious Disease & Virology, Metabolism Research

Images & Validation

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Key Properties

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CAS Number	161922-40-3
MW	215.04
Purity	99.14%
Formula	C₅H₈Cl₂N₂O₃
SMILES	[C@H](C(O)=O)(N)[C@]1(ON=C(Cl)C1)[H].Cl
Target	Transferase,Parasite
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (15.35 mM);DMSO:80 mg/mL (372.02 mM)

Bioactivity

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In Vitro	Methods: HepG2 cells were treated with Acivicin hydrochloride (0.1-50 μM, 5 days) and cell viability was measured. Results: Its IC50 value in HepG2 cells was 0.7 μM. Read more...

Storage & Handling

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Storage	store under nitrogen \| store at 4°C \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AT125 hydrochloride, AT-125 hydrochloride, U42126 hydrochloride, U-42126 hydrochloride

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Compound Identifiers

PubChem CID

155905759 ↗

Key Properties

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No computed properties available.

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