Alethine

SKU: orb1698565

Description

Alethine (β-Alethine) is a bioactive small molecule with antitumor properties, functioning in part by upregulating TNFα to enhance T-cell mediated cytotoxicity. It is utilized in research exploring immunomodulation and oncology, with applications in both in vitro cell-based assays and in vivo tumor model studies.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	646-08-2
MW	294.44
Purity	99.78% (May vary between batches)
Formula	C₁₀H₂₂N₄O₂S₂
SMILES	N(CCSSCCNC(CCN)=O)C(CCN)=O
Target	TNF,Apoptosis
Solubility	DMSO:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

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In Vivo

Alethine (beta-alethine) (1 ng/kg to 100 micrograms/kg) successfully treat NS-1 myeloma in a syngeneic murine tumor model (NS-1 myeloma) when early interventions . Although there are indications in this model that beta-alethine is also effective when intervention is late, beta-alethine is ineffective in an allogeneic murine melanoma model (Cloudman S-91 melanoma).

In Vitro

Alethine (Beta-alethine) (10 ng/ml) (a) adapts murine liver cells to culture (53 colonies/10(6) cells versus none in controls), (b) delays aging of human IMR-90 fetal lung fibroblasts (102 population doubling levels versus 47 in controls, producing 3 x 10(16) greater biomass), and (c) markedly stimulates antibody-producing plaque-forming cells from murine splenocytes (16,875/10(6) cells versus 55/10(6) cells in controls) or human peripheral blood leukocytes (1826/10(6) cells versus 0/10(6) cells in controls).

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Alethine, b-Alethine, beta-Alethine, β-Alethine, TNF-α

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Compound Identifiers

PubChem CID

69532 ↗

Key Properties

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No computed properties available.

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Alethine (orb1698565)

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CAS Number:	104071-84-3
MW:	562.70
Formula:	C₂₆H₃₄N₄O₆S₂

Alethine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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