Amatuximab Antibody

SKU: orb1980770

Description

Amatuximab (MORab-009) is a humanized chimeric monoclonal antibody targeting mesothelin (MSLN) on cancer cells. It exhibits antitumor activity and has been investigated in preclinical and clinical studies for mesothelin-expressing solid tumors, such as mesothelioma and pancreatic cancer.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	931402-35-6
MW	144.31 kDa
Purity	95.2% (SDS-PAGE); 98.4% (SEC-HPLC)
Target	Mesothelin,Others

Bioactivity

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In Vivo	In tumor xenograft studies, the combination treatment of Amatuximab and chemotherapy significantly reduces the growth of mesothelin-expressing tumors to a greater extent compared to the use of Amatuximab or chemotherapy alone. Read more...
In Vitro	Amatuximab (MORAb-009) is a murine-human chimeric monoclonal antibody with selective affinity for mesothelin (MSLN). In vitro, Amatuximab can induce antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cell lines expressing mesothelin and inhibit heterotypic cell adhesion between mesothelin-positive tumor cells and tumor cells expressing CA125. Read more...

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MORab-009, Amatuximab

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Gene Symbol

Mesothelin,Others

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