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AMG-47a

SKU: orb1300050

Description

AMG-47a is a potent small molecule inhibitor of lymphocyte-specific protein tyrosine kinase (Lck), suppressing T-cell proliferation. It also acts as a selective degrader of the KRASG12V oncoprotein, as demonstrated in cellular studies, making it a valuable tool for oncology and immunology research.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number882663-88-9
MW535.56
Purity98.00%
FormulaC29H28F3N5O2
SMILESCc1ccc(cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1)C(=O)Nc1cccc(c1)C(F)(F)F
Targetp38 MAPK,Src,JAK,Ras,VEGFR,Kras
SolubilityDMSO:34 mg/mL (63.48 mM)

Bioactivity

Target IC50
Lck:0.2 nM (IC50)|p38α:3 nM (IC50)|VEGF2:1 nM (IC50)|JAK3:72 nM (IC50)|MLR:30 nM (IC50)|IL-2:21 nM (IC50)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Janus kinase, JAK, immune, kinases, Inhibitor, inhibit, family, Lck, AMG 47a, AMG47a, AMG-47a, cell, cytoplamic, p38 MAPK, p38MAPK, receptor, signal, specific, Src, responses, VEGFR, Vascular endothelial growth factor receptor, transduction, tyrosine

Similar Products

  • AMG-47a [orb1220556]

    >98% (HPLC)

    882663-88-9

    535.56

    C29H28F3N5O2

    25 mg, 5 mg, 10 mg, 50 mg, 1 g, 500 mg, 200 mg, 100 mg
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Key Properties

No computed properties available.

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AMG-47a (orb1300050)

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% Tween 80 +
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Available Sizes

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1 mg
$ 80.00
5 mg
$ 130.00
1 ml x 10 mM (in DMSO)
$ 140.00
10 mg
$ 200.00
25 mg
$ 310.00
50 mg
$ 430.00
100 mg
$ 620.00
DispatchUsually dispatched within 3-5 working days
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