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β-Amyrenonol

SKU: orb3054234

Description

Standard reference

Images & Validation

Key Properties

CAS Number38242-02-3
MW440.7
Purity>98% (HPLC)
FormulaC30H48O2

Bioactivity

In Vitro
β-Amyrenonol (11-Oxo-β-amyrin) inhibits cell growth of HL60 cells with an IC50 value of 26.3 μM. β-Amyrenonol (11-Oxo-β-amyrin) (100 μM) significantly reduces lipopolysaccharide-induced TNFα release in THP-1 cells. CYP88D6 is characterized by in vitro enzymatic activity assays and shown to catalyze the sequential two-step oxidation of β-amyrin at C-11 to produce β-Amyrenonol (11-Oxo-β-amyrin). CYP88D6 coexpressed with β-amyrin synthase in yeast also catalyzed in vivo oxidation of β-amyrin to β-Amyrenonol.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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β-Amyrenonol (orb3054234)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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