Anifrolumab Antibody

SKU: orb1944782

Description

Anifrolumab(MEDI-546) is a potent type I interferon (IFN) receptor antagonist, a human monoclonal antibody that targets IFN.Anifrolumab inhibits the activity of type I interferon and is used for the prevention and treatment of systemic lupus erythematosus (SLE).

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	1326232-46-5
MW	144.92 kDa
Purity	> 95%
Target	IFNAR
Solubility	DMSO:60 mg/mL

Bioactivity

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Target IC50

ISRE:0.3 nM

In Vitro

Anifrolumab induces sustained reduction of surface IFNAR1 and abrogates STAT1 phosphorylation at a concentration of 67.7 nM for 20 minute. Anifrolumab suppresse the differentiation of B cells into plasma cells at concentration of 1 and 10 μg mL for 6 or 7 day. Anifrolumab inhibits type I IFN-induced ISRE signaling, with IC50 ranging from 0.004 to 0.3 nM fo the IFN-α subtypes, and 0.03 nM and 0.07 nM for IFN-β and IFN-ω, respectivel. t a concentration of 67.7 nM, Anifrolumab dose-dependently inhibits IFN-α production from pDCs in response to CpG-A or DNA-IC stimulation, inhibiting 87-95% of IFN-α productio.

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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MEDI546, MEDI-546, MEDI 546, MDX1333, MDX-1333, MDX 1333, IFNAR, Anifrolumab

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Quick Database Links

Gene Symbol

IFNAR

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