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(-)-Anonaine

SKU: orb1684762

Description

(-)-Anonaine is a natural product with broad bioactivity, including antimalarial, antibacterial, and anticancer properties. Research demonstrates it induces apoptosis and DNA damage in HeLa and h1299 cancer cells via Bax/caspase pathways, supporting its use in oncology and pharmacology studies.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research

Images & Validation

Key Properties

CAS Number1862-41-5
MW265.31
Purity99.60%
FormulaC17H15NO2
SMILESC=12C3=C4C(=CC1CCN[C@@]2(CC=5C3=CC=CC5)[H])OCO4
TargetGST,Apoptosis,Antioxidant,Parasite,Antifungal
SolubilityDMSO:2.66 mg/mL (10.03 mM)

Bioactivity

Target IC50
HepG2 cells:38.3 ± 2.3 μg/ml(CC50)|HepG2 cells:23.2 ± 2.7 μg/ml
In Vitro
(-)-Anonaine (50-200 μM ; 24h ; ) exhibited significant inhibition to cell growth and migration activities on human lung cancer H1299 cells. (-)-Anonaine (10-200 μM) significant nuclear damages of H1299 cells were observed treatment in a comet assay, whereas higher concentrations (6 and 30 mM) of (-)-anonaine concentrations were required to cause DNA damages in an in vitro plasmid cleavage assay.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

p53, Fungal, Apoptosis, Antioxidant, Anonaine, Caspase, Bcl-2, ()Anonaine, ( ) Anonaine, P. falciparum
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Key Properties

No computed properties available.

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Protocol Information

(-)-Anonaine (orb1684762)

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5 mg
$ 860.00
DispatchUsually dispatched within 3-5 working days
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