ERBB2/HER2/CD340 Antibody

SKU: orb1806342

Description

Anti-ERBB2 / HER2 / CD340 Reference Antibody is expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hukappa. It has a predicted MW of 143.9 kDa.

Research Area

Immunology & Inflammation

Images & Validation

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Item 1 of 5

Tested Applications	ELISA, FA, FACS, In vivo
Reactivity	Human, Monkey, Mouse

Key Properties

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Clonality	Monoclonal
Target	ERBB2 / HER2 / CD340
Source/Expression System	CHO
Molecular Weight	145.44 kDa
Purity	>95%
Purification	Protein A
Endotoxin	<0.001 EU/ug
Conjugation	Unconjugated

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Buffer/Preservatives	100 mM Proline/Acetic acid 20mM Arginine pH 5.0
Concentration	Batch dependent
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Anti-ERBB2 / HER2 / CD340 Reference Antibody (pertuzumab) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

The purity of Anti-ERBB2 / HER2 / CD340 Reference Antibody (pertuzumab)is more than 99.02% ;determined by SEC-HPLC.

Immobilized human HER2(23 652) His at 2 μg/mL can bind Anti-ERBB2 / HER2 / CD340 Reference Antibody (pertuzumab);EC50=0.01375μg/mL.

BT474 cells were stained with Anti-ERBB2 / HER2 / CD340 Reference Antibody (pertuzumab) and negative control protein respectively; washed and then followed by PE and analyzed with FACS; EC98=0.2994 μg/mL.

Pertuzumab+trastuzumab inhibited the tumor growth of NCI-N87 on Balb/c nude mice. The result showed significant anti-tumor effects; with an tumor inhibition rate (TGI) of 73.8% at 5 mpk at D37.

Quick Database Links

Gene Symbol

ERBB2 / HER2 / CD340

UniProt

P04626

UniProt Details

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No UniProt data available

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Protocol Information

FACS

Fluorescence-Activated Cell Sorting (FC, Flow cytometry)

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ELISA

Enzyme-linked Immunosorbent Assay (EIA)

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