CD271 Antibody (APC)

SKU: orb154442

Description

Mouse monoclonal antibody conjugated to APC which recognizes CD271 that is low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. It can mediate cell survival as well as cell death of neural cells. CD271 is useful for the detection of all cells expressing p75NTR on their surface, such as motor neurons cholinergic basal forebrain neurons, activated Schwann cells, olfactory ensheathing glial cells.

Research Area

Apoptotic, Cancer, Developmental Biology, Epigenetics, Neuroscience, Signaling Pathways

Images & Validation

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Tested Applications	FC
Reactivity	Feline, Ferret, Human, Primate, Rabbit
Application Notes	Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Extracellular and intracellular staining.

Key Properties

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Antibody Type	Primary Antibody
Clonality	Monoclonal
Isotype	Mouse IgG1
Clone No.	NGFR5
Immunogen	Purified CD271 protein isolated from human melanoma cell line A875
Target	CD271
Purification	Purified antibody is conjugated with activated allophycocyanin (APC) under optimum conditions and unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.
Conjugation	APC

Storage & Handling

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Storage	Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Buffer/Preservatives	Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Disclaimer	For research use only

Alternative Names

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TNFRSF16, NGFR, p75NTR, p75NGFR

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Separation of REH cells stained using anti-human CD271 (NGFR5) APC antibody (concentration in sample 0.33 µg/ml, red) from unstained REH cells (grey) in flow cytometry analysis (intracellular staining).

Quick Database Links

Gene Symbol

CD271

UniProt

P08138

NCBI Gene ID

4804

UniProt Details

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No UniProt data available

NCBI Gene Details

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No NCBI Gene data available

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Protocol Information

Flow Cytometry

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