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Anti-inflammatory agent 49

SKU: orb1941713

Description

Anti-inflammatory agent 49 is a selective inhibitor that disrupts the Drp1-Fis1 protein interaction and suppresses Drp1 GTPase activity. This small molecule serves as a valuable research tool for investigating mitochondrial fission mechanisms in models of neurodegenerative and cardiovascular diseases, both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number851471-44-8
MW466.52
Purity99.97% (May vary between batches)
FormulaC21H22N8O3S
SMILESO=C1NC(=O)N(C(N)=C1N(C(=O)CSC=2N=C3N=C(C=C(N3N2)C)C)C)CC=4C=CC=CC4
TargetOthers,GTPase,Dynamin
SolubilityDMSO:80 mg/mL (171.48 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.07 mM)

Bioactivity

In Vivo
The anti-inflammatory agent 49 (10 mg/kg, every 8 hours for 72 hours) effectively treats endotoxemia induced by LPS in mice .
In Vitro
In H9c2 cells, the anti-inflammatory agent 49 (2 µM; 16 hours) reduced the percentage of cells with fragmented mitochondria. The percentage of fragmented cells decreased from 22% (LPS + Veh) to 9% (LPS + SC9), compared to 4% in the absence of LPS.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

GTPase

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

1 mg
$ 130.00
5 mg
$ 260.00
10 mg
$ 390.00
25 mg
$ 740.00
50 mg
$ 1,130.00
100 mg
$ 1,520.00
DispatchUsually dispatched within 5-10 working days
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