Anti-inflammatory agent 55

SKU: orb1944213

Description

Compound 9j, a Coixol derivative, is a potent anti-inflammatory small molecule that inhibits the NF-κB pathway. It suppresses pro-inflammatory mediators like iNOS, TNF-α, IL-6, and IL-1β in vitro (IC₅₀ = 0.8 μM for NO in RAW264.7 cells) and demonstrates efficacy in vivo in murine edema models.

Research Area

Cell Biology, Immunology & Inflammation, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	2924156-51-2
MW	373.32
Formula	C₁₇H₁₅N₃O₇
SMILES	O=[N+](C1=CC=C(O1)/C=C/C(NCCN2C3=CC=C(OC)C=C3OC2=O)=O)[O-]
Target	Interleukin,TNF,NO Synthase,Others,NF-κB

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Compound Identifiers

PubChem CID

167437624 ↗

Key Properties

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No computed properties available.

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