Anticancer agent 110

SKU: orb1944419

Description

Anticancer agent 110 is an anticancer compound with cytotoxic, antitumor, and antileukemic activity that triggers DNA damage and apoptosis and is used in the study of chronic granulocytic leukemia.

Research Area

Cell Biology

Images & Validation

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Key Properties

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CAS Number	887349-03-3
MW	380.4
Formula	C₁₈H₁₃FN₆OS
SMILES	O=C(NC1=NC=C(S1)CC2=CC=C(F)C=C2)C3=CC=C(C=C3)N4N=NN=C4
Target	Apoptosis

Bioactivity

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Target IC50	K562 cells:0.7 μM
In Vitro	Anticancer agent 110 exhibited an inhibitory effect on leukemic K-562 cells at concentration ranging from 0.01 μM to 100 μM, with an IC50 value of 0.7 μM the compound triggered higher levels of DNA damage in K-562 cells after 24 hours of treatment at concentration of 70 nM and 700 nM, and also caused cellular morphological changes, exhibiting apoptotic features. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

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Apoptosis

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Compound Identifiers

PubChem CID

7465200 ↗

Key Properties

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No computed properties available.

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