Antitumor agent-169

SKU: orb3134600

Description

Antitumor agent-169 (Compound B3) is a dual inhibitor of PD-1/PD-L1 interaction and PARP7, with IC50 values of 0.426 μM and 2.50 nM, respectively. It exhibits affinity for human PD-L1 with a Ki of 20.2 nM and can restore T cell function by increasing IFN-γ secretion. Antitumor agent-169 inhibits cell viability in MDA-MB-231 and Jurkat T cells, demonstrates antitumor activity against melanoma in mouse models, and possesses favorable pharmacokinetic properties.

Images & Validation

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Key Properties

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Formula	C₅₅H₆₉F₃N₁₀O₁₀
Target	PD-1/PD-L1,PARP

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

PD-1/PD-L1,PARP

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