AP-1/NF-κB activation inhibitor 1

SKU: orb1685254

Description

This small molecule inhibitor potently suppresses AP-1 and NF-κB-driven transcriptional activation (IC50 ~1 µM) without affecting basal β-actin promoter activity. It effectively reduces pro-inflammatory cytokine production, such as IL-2 and IL-8, making it a valuable tool for studying inflammation and immune signaling pathways in cellular models.

Research Area

Cell Biology, Molecular Biology, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	188936-12-1
MW	344.25
Purity	99.74%
Formula	C₁₃H₁₁F₃N₄O₄
SMILES	CCOC(=O)c1cnc(nc1NN1C(=O)C=C(C)C1=O)C(F)(F)F
Target	NF-κB,DNA/RNA Synthesis
Solubility	DMSO:225 mg/mL (653.59 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (14.52 mM)

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AP 1/NF κB activation inhibitor 1, AP-1/NF-kappaB activation inhibitor 1, AP-1/NF-kB activation inhibitor 1, AP1/NFκB activation inhibitor 1, AP-1/NF-κB activation inhibitor 1, AP-1, DNA Synthesis, DNASynthesis, NFkB, NFκB, NF-kB, NF-κB, RNASynthesis, RNA Synthesis

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Compound Identifiers

PubChem CID

44289488 ↗

Key Properties

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No computed properties available.

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