Apigenin

SKU: orb1306215

Description

Apigenin

Research Area

Cell Biology, Metabolism Research

Images & Validation

−

Key Properties

−

CAS Number	520-36-5
MW	270.24
Purity	99.66%
Formula	C₁₅H₁₀O₅
SMILES	OC1=CC=C(C=C1)C1=CC(=O)C2=C(O)C=C(O)C=C2O1
Target	Autophagy,Cytochromes P450,Endogenous Metabolite
Solubility	H2O:< 1 mg/mL (insoluble or slightly soluble);DMSO:255 mg/mL (943.61 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (18.5 mM)

Bioactivity

−

Target IC50	CYP2C9:2 μM (Ki)\|Microsomes (Rat):25.73 μM\|Microsomes (human):58.37 μM
In Vivo	Apigenin at a dosage of 12.5 mg/kg enhance the proliferation of cells in the dentate gyrus region o the hippocampus in adult mice. It also downregulate the production of IL-4 in ovalbumin-immunized BAL-/- mice. Additionally, apigenin significantly increases bot the weight o the uterus an the ove All concentration of estrogen receptor (ER)-α in f Male mice (64), while inhibitin the growth of prostate and breast cancer cells vi the estrogen receptor β1. This compound inhibits lung metastasis of melanoma by blockin the interaction between tumor cells and endothelial cells. furthermore , apigenin reduces IGF-I levels in prostate xenografts and increase the content of IGFBP-3, a protein that binds IGF-I in the bloodstream. Read more...
In Vitro	Apigenin inhibit the activity of protein kinase C, mitogen-activated protein kinase, an the transformation of C3HI mouse embryo fibroblasts, as well as downstream oncogenes in NIH3T3 cells transformed by v-Ha-ras. It also suppresse the activity and expression of cyclooxygenase-2 and nitric oxide synthase-2 in mouse macrophages induced by LPS and effectively block the upregulation o the cell adhesion molecule-1 in human endothelial cells triggered by TNFα. Moreover, apigenin inhibit the expression of HIF-1α and VEGF in human ovarian cancer cells throug the PI3K/Akt/p70S6K1 and HDM2/p53 signaling pathways, reduce the phosphorylation levels of cellular proteins induced by TPA, and inhibit the expression of c-jun and c-fos also induced by TPA. It reverse the transformed phenotype of NIH3T3 cells with v-H-ras. In Chinese hamster ovary cells, apigenin prevents mutations caused b the toxicity gene induced by nitropyrene. It block the peroxisome proliferator-activated kinase and MAPK in hepatocytes ex vivo. In epithelial and fibroblast cells, apigenin causes reversible blocks at G2/M and G0/G1 phases by inhibiting p34 (cdc2) kinase activity, accompanied by an increase in p53 protein stability. Read more...

Storage & Handling

−

Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Disclaimer	For research use only

Alternative Names

−

inhibit, NSC 83244, LY080400, LY-080400, LY 080400, NSC83244, NSC-83244, Inhibitor, 4',5,7-Trihydroxyflavone, Apigenol, Apigenin, Autophagy, C.I. Natural Yellow 1, CYP2C9, CYPs, Cytochrome P450

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Compound Identifiers

PubChem CID

5280443 ↗

Key Properties

−

No computed properties available.

Documents Download

Datasheet

Product Information

Download

Request a Document

Protocol Information

Find More Protocols

Sang A Kwak 1, Jane J Lee 1, Ju Hong Park 2, Nami Joo 1 Phytochemical Profiling and Anti-Inflammatory Effects of Aerial and Underground Parts of Apium graveolens var. rapaceum (Celeriac): Potential Health Benefits of Discarded Aerial Parts Food Sci Nutr, (2025)

PubMed: 41049417

Apigenin (orb1306215)

Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

No reviews yet

Purity:	>=98%
MW:	740.7
Formula:	C₃₃H₄₀O₁₉

Apigenin

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Similar Products

Chamomile Flavonoid Standards Kit [orb322044]

Berry Flavonoid Standards Kit [orb322054]

Citrus Flavonoids Standards Kit [orb322057]

Celery Standards Kit [orb322058]

Apigenin-8-C-beta-D-glucopyranosyl-6-C-[alpha-L-rhamnopyranosyl-(1->2)]-beta-glucopyranoside [orb1736124]

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

Apigenin (orb1306215)

Step 1: Enter information below

Step 2: Enter the in vivo formulation

Available Sizes

Email

UK Office

US Office

CN Office

Distributors