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Arcyriaflavin A

SKU: orb1704942

Description

Arcyriaflavin A, a natural product isolated from Eudistoma sp., is a potent inhibitor of CDK4, CDK1, and CaMKII kinases. It also demonstrates cytotoxic activity against HCT-116 and NCI-H460 cancer cell lines. This compound is a valuable research tool for studying cell cycle regulation and kinase signaling pathways in vitro.

Research Area

Infectious Disease & Virology, Metabolism Research

Images & Validation

Key Properties

CAS Number118458-54-1
MW325.32
Purity99.64% (May vary between batches)
FormulaC20H11N3O2
SMILESO=C1NC(=O)C2=C1C1=C(NC3=C1C=CC=C3)C1=C2C2=C(N1)C=CC=C2
TargetAntifungal,Endogenous Metabolite
SolubilityDMSO:20 mg/mL (61.48 mM)

Bioactivity

In Vitro
Arcyriaflavin A has inhibitory effects on D1-CDK4, B-CDK1 and CaMKII, with IC50 values ​​of 0.14μM, 1.13μM and 0.025μM, respectively. Arcyriaflavin A has inhibitory effects on HCT-116 and NCI-H460 cells, with IC50 values ​​of 0.85μM and 0.59μM, respectively.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Endogenous Metabolite, EndogenousMetabolite, Microbial Metabolite, Arcyriaflavin A
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

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1 mg
$ 90.00
5 mg
$ 160.00
10 mg
$ 230.00
25 mg
$ 370.00
50 mg
$ 540.00
DispatchUsually dispatched within 5-10 working days
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