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Arecoline HBr

SKU: orb1225395

Description

Arecoline Hydrobromide is a muscarinic acetylcholine receptor agonist.(In Vitro):Arecoline hydrobromide induces the generation of reactive oxygen species and cell cycle arrest at the G1/G0 phase in HaCaT cells without affecting the expression of p21/Cip1. Arecoline hydrobromide-induced epithelial cell death at higher concentrations is caused by oxidative trauma without eliciting apoptosis. Arecoline hydrobromide upregulates the expression of the following stress-responsive genes: hemeoxygenase-1; ferritin light chain; glucose-6-phosphate dehydrogenase; glutamatecysteine ligase catalytic subunit; and glutathione reductase.

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Key Properties

CAS Number300-08-3
MW236.11
Purity>98% (HPLC)
FormulaC8H13NO2·HBr
SMILESBr.COC(=O)C1=CCCN(C)C1
TargetAChR
SolubilityEthanol: 10 mg/mL (42.35 mM); Water: 47 mg/mL (199.05 mM); DMSO: 47 mg/mL (199.05 mM)

Bioactivity

In Vitro
Arecoline hydrobromide induces the generation of reactive oxygen species and cell cycle arrest at the G1/G0 phase in HaCaT cells without affecting the expression of p21/Cip1. Arecoline hydrobromide-induced epithelial cell death at higher concentrations is caused by oxidative trauma without eliciting apoptosis. Arecoline hydrobromide upregulates the expression of the following stress-responsive genes: hemeoxygenase-1; ferritin light chain; glucose-6-phosphate dehydrogenase; glutamatecysteine ligase catalytic subunit; and glutathione reductase.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Arecoline HBr (orb1225395)

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