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Aripiprazole

SKU: orb1226597

Description

Aripiprazole(Abilify) is a human 5-HT1A receptor partial agonist with a Ki of 4.2 nM.(In Vitro):Aripiprazole potently activates D2 receptor-mediated inhibition of cAMP accumulation.Aripiprazole shows a greater anti-inflammatory effect on TNF-α, IL-13, IL-17α and fractalkine.(In Vivo):Aripiprazole (0-3 mg/kg, IP, daily) shows some anxiolytic properties.

Images & Validation

Key Properties

CAS Number129722-12-9
MW448.39
Purity>98% (HPLC)
FormulaC23H27Cl2N3O2
SMILESC1CC(=O)NC2=C1C=CC(=C2)OCCCCN3CCN(CC3)C4=C(C(=CC=C4)Cl)Cl
Target5-HT Receptor
SolubilityDMSO: 90 mg/mL (200.71 mM)

Bioactivity

In Vivo
Aripiprazole (0-3 mg/kg, IP, daily) shows some anxiolytic properties. Animal model: WAG/Rij rats (N = 6 per dose, 6 months, administration of a mixture of tiletamine/zolazepam). Dosage: 0, 0.3, 1, 3 mg/kg. Administration: IP, 1 mL/kg, every day at 5 p. m. until the end of the experiments. Result: Showed some anxiolytic properties with the 1 mg/kg dose being the most active.
In Vitro
Aripiprazole potently activates D2 receptor-mediated inhibition of cAMP accumulation. Aripiprazole shows a greater anti-inflammatory effect on TNF-α, IL-13, IL-17α and fractalkine.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

OPC 31 | OPC 14597

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Aripiprazole (orb1226597)

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1 g
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