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AS1810722

SKU: orb1217490

Description

AS1810722 is an orally active and potent STAT6 inhibitor(IC50 :1.9 nM). AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722, a derivative of fused bicyclic pyrimidine, has the potential for allergic diseases such as asthma and atopic diseases research.

Images & Validation

Key Properties

CAS Number909561-15-5
MW477.52
Purity>98% (HPLC)
FormulaC25H25F2N7O
SMILESO=C(N)CN1CCN(C2=CC=C(NC3=NC=C4C(N(CC5=CC(F)=CC(F)=C5)C=C4)=N3)C=C2)CC1
TargetP450
SolubilityDMSO : 62.5 mg/mL (130.89 mM; Need ultrasonic)

Bioactivity

In Vivo
Animal model: Female Balb/c mice asthmatic model by intraperitoneal injection of ovalbumin (OVA)-containing aluminum hydroxide gel. Dosage: 0.03-0.3 mg/kg. Administration: Orally; 30 min before, and 24 and 48 h after OVA exposure. Result: Suppressed eosinophil infiltration in the lung in a dose-dependent manner.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Similar Products

  • AS1810722 [orb1298418]

    99.13%

    909561-15-5

    477.51

    C25H25F2N7O

    1 mg, 25 mg, 50 mg, 10 mg, 1 ml x 10 mM (in DMSO), 5 mg
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AS1810722 (orb1217490)

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Available Sizes

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100 mg
200 mg
500 mg
5 mg
$ 350.00
10 mg
$ 540.00
25 mg
$ 880.00
50 mg
$ 1,240.00