Asaraldehyde

SKU: orb1304970

Description

Asaraldehyde

Research Area

Immunology & Inflammation, Neuroscience

Images & Validation

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Key Properties

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CAS Number	4460-86-0
MW	196.20
Purity	99.85% (May vary between batches)
Formula	C₁₀H₁₂O₄
SMILES	COC1=CC(OC)=C(C=O)C=C1OC
Target	COX
Solubility	H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2.00 mg/mL (10.19 mM);Ethanol:16.00 mg/mL (81.55 mM);DMSO:50.00 mg/mL (254.84 mM)

Bioactivity

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Target IC50	COX-2:100 μg/mL.
In Vivo	Asaraldehyde (100 μg/mL) exhibits a higher inhibitory effect on COX-2. At the same concentration, it mildly inhibits the activity of prostaglandin H synthase-1 (3.32%) and significantly inhibits prostaglandin H synthase-2 (52.69%). Moreover, Asaraldehyde downregulates C/EBPβ, C/EBPδ, and C/EBPα and suppresses the expression of PPARγ1, PPARγ2, and acetyl-CoA carboxylase.
Cell Research	3T3-L1 cells are seeded in 96-well plates at a concentration of 104 /well. Twenty-four hours after seeding, the cells are treated with 100 μg/mL of Asaraldehyde for 24 hours or for the whole 8-day differentiation period. Fully differentiated adipocytes are also treated with 100 μg/mL of Asaraldehyde for 24 hours-72 hours to test the cytotoxicity. At the end of treatment, cells are cultured with MTT at a final concentration of 0.5 mg/mL for another 4 hours. The purple MTT formazan is dissolved by DMSO and the absorbance at 570 nm is taken with a spectrophotometer. The absorbance is proportional to the viability of adipocytes.(Only for Reference)

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Inhibitor, inhibit, Cyclooxygenase, COX-2, COX, Asaraldehyde, Asaronaldehyde, Asarylaldehyde, 2,4,5-trimethoxy-Benzaldehyde

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Compound Identifiers

PubChem CID

20525 ↗

Key Properties

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No computed properties available.

Protocol Information

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Purity:	>98% (HPLC)
CAS Number:	4460-86-0
MW:	196.2
Formula:	C₁₀H₁₂O₄

Asaraldehyde

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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Asarylaldehyde [orb1222254]

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