Aspergillus fumigatus Dihydroorotate Dehydrogenase Protein, His Tag

SKU: orb3158086

Description

Aspergillus fumigatus dihydroorotate dehydrogenase (DHODH) is an essential mitochondrial enzyme in the de novo pyrimidine biosynthesis pathway, required for fungal DNA and RNA synthesis. Because A. fumigatus relies on DHODH for growth and survival, the enzyme has emerged as a validated antifungal drug target, exemplified by inhibitors such as olorofim

Images & Validation

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Application Notes	This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 49.5 kDa. The protein migrates as 55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).

Key Properties

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Expression System	E. coli
Target	Dihydroorotate Dehydrogenase
Reactivity	Aspergillus
Tag	C-10×His
Molecular Weight	49.5 kDa
Expression Region	Ala 89 - Gln 531
Purity	90%
Conjugation	Unconjugated

Storage & Handling

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Storage	-70°C
Form/Appearance	Liquid
Buffer/Preservatives	50 mM Tris, 150 mM NaCl, pH 8.0
Expiration Date	6 months from date of receipt.
Dry Ice Shipping	Please note: This product requires shipment on dry ice. A dry ice surcharge will apply.
Disclaimer	For research use only

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Quick Database Links

Gene Symbol

Dihydroorotate Dehydrogenase

UniProt

A0A229W7A4

RefSeq:A0A229W7A4

UniProt Details

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No UniProt data available

NCBI Reference Sequences

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Associated Accession Numbers

Curated reference sequences for the gene transcript and protein product

RefSeq	A0A229W7A4

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