Astaxanthin

SKU: orb1225008

Description

Astaxanthin is a natural dietary component. Natural astaxanthin is generally recognized as safe (GRAS) by the FDA(In Vitro):Astaxanthin (50, 100, 150, 200 μM; 48 h) inhibits the proliferation of DU145 cells (IC50<200 μM).Astaxanthin (200 μM; 24 h) reduces the expression of STAT3 and the related pathway proteins (at both protein and mRNA levels) by inhibiting proliferation, increasing apoptosis and weakening migration and invasionAstaxanthin protects RPE cells from abnormal activation and oxidative stress (induced by high glucose) by down-regulating VEGF in high glucose at protein levels.Astaxanthin (1-50 μM; 72 h) upregulates protein expression of PPARγ in time- and dose-dependent manners in K562 cells.(In Vivo):Astaxanthin (200 mg/kg; intragastric administration; once daily for 3 weeks) inhibits the growth of DU145 tumor xenografts in nude mice.Astaxanthin (125 or 500 mg/kg; in animal feedings; 7 days) provides significant cardioprotection and reduces oxidative stress in rats.

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Key Properties

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CAS Number	472-61-7
MW	596.84
Purity	>98% (HPLC)
Formula	C₄₀H₅₂O₄
SMILES	O=C1C(C)=C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)C([C@@H](O)CC2(C)C)=O)C(C)(C)C[C@@H]1O
Target	Others
Solubility	Soluble in Chloroform

Bioactivity

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In Vivo

Astaxanthin (200 mg/kg; intragastric administration; once daily for 3 weeks) inhibits the growth of DU145 tumor xenografts in nude mice. Astaxanthin (125 or 500 mg/kg; in animal feedings; 7 days) provides significant cardioprotection and reduces oxidative stress in rats. Animal model: Nude mice (approximately 20 g; DU145 tumor xenografts model). Dosage: 200 mg/kg. Administration: Intragastric administration; once daily for 3 weeks. Result: Exerted a significant inhibitory effect on tumor growth. Animal model: Female C57BL/6 mice (7 weeks old). Dosage: 125 or 500 mg/kg. Administration: In animal feedings; 7 days. Result: Significantly reduced mean infarct size in the two treated groups (125 and 500 mg/kg) to 45.1% and 39.1%, respectively. Exhibited myocardial salvage of 26 and 36% for 125 and 500 mg/kg groups, respectively. Significantl reduced level of 9-HETE in a dose-dependent manner. 9-HETE is a regioisomer oxidation product of arachidonic acid believed to be a product of free radical-mediated oxidation.

In Vitro

Astaxanthin (50, 100, 150, 200 μM; 48 h) inhibits the proliferation of DU145 cells (IC50<200 μM). Astaxanthin (200 μM; 24 h) reduces the expression of STAT3 and the related pathway proteins (at both protein and mRNA levels) by inhibiting proliferation, increasing apoptosis and weakening migration and invasionAstaxanthin protects RPE cells from abnormal activation and oxidative stress (induced by high glucose) by down-regulating VEGF in high glucose at protein levels. Astaxanthin (1-50 μM; 72 h) upregulates protein expression of PPARγ in time- and dose-dependent manners in K562 cells. Apoptosis Analysis Cell line: DU145 cells. Concentration: 200 μM (pre-incubation). Incubation time: 24 h. Result: Increased the percentage of apoptotic cells from 8.5% to 13.1% (compared to blank control). Cell Migration Assay Cell line: DU145 cells. Concentration: 200 μM. Incubation time: 24 h. Result: Decreased the migration and invasion of DU145 cells (about 41% of cells could not pass from one chamber to another, and 36% cells could not pass through the transwell membrane as compared to the control group). Cell Proliferation Assay Cell line: ARPE-19 cells. Concentration: 50 μM (pre-incubation). Incubation time: 7 days. Result: Significantly decreased cell proliferation exposed to high glucose. Western blot analysis. Cell line: DU145 cells. Concentration: 200 μM. Incubation time: 24 h. Result: Reduced the expression of STAT3 at both protein and mRNA levels (downregulated the protein expression of JAK2, BCL-2 and NF-κB and upregulated the protein expression of BAX, Caspase3 and Caspase9). Western blot analysis. Cell line: K562 cells. Concentration: 1-50 μM. Incubation time: 72 h. Result: Significantly promoted PPARγ protein expression in time- and dose-dependent manners.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Purity:	99.79% (May vary between batches)
CAS Number:	472-61-7
MW:	596.84
Formula:	C₄₀H₅₂O₄

CAS Number:	7542-45-2
MW:	596.84
Formula:	C₄₀H₅₂O₄

CAS Number:	112421-21-3
MW:	1073.66
Formula:	C₇₂H₁₁₂O₆

CAS Number:	123159-02-4
MW:	835.25
Formula:	C₅₆H₈₂O₅

CAS Number:	514-76-1
MW:	592.81
Formula:	C₄₀H₄₈O₄

Astaxanthin

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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