Atazanavir sulfate

SKU: orb1310937

Description

Atazanavir sulfate

Research Area

Immunology & Inflammation, Infectious Disease & Virology, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry

Images & Validation

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Key Properties

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CAS Number	229975-97-7
MW	802.93
Purity	99.67%
Formula	C₃₈H₅₂N₆O₇·H₂SO₄
SMILES	OS(O)(=O)=O.COC(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)[C@@H](O)CN(Cc1ccc(cc1)-c1ccccn1)NC(=O)[C@@H](NC(=O)OC)C(C)(C)C)C(C)(C)C
Target	P-gp,SARS-CoV,HIV Protease,Endogenous Metabolite,Cytochromes P450,TLR
Solubility	H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.49 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (68.5 mM)

Bioactivity

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Target IC50	HIV protease:2.66 nM(Ki)
In Vivo	Atazanavir (30 mM) treatment of LS180V cells resulted in a 2.5-fold increase in the expression of P-gp associated with immune responses and a decrease in intracellular Rh123. In glioblastoma cell lines U251, T98G, and LN229, Atazanavir inhibited cell growth and significantly elevated levels of GRP78 and CHOP proteins. Additionally, Atazanavir inhibited the human 20S proteasome. In U251 glioma cells, Atazanavir exposure led to a marked increase in polyubiquitinated proteins of various sizes. When applied to H9 cells infected with a virus, Atazanavir obstructed the proteolytic cleavage of the viral gag precursor p55 polyprotein, with an IC50 of approximately 47 nM. Atazanavir demonstrated potent antiviral activity against the RF/MT-2 strain, with an EC50 of 3.89 nM. Finally, at 30 μM, Atazanavir altered the magnitude of endoplasmic reticulum stress and the expression of UPR genes in HepG2 cells. Read more...
Cell Research	To determine cytotoxicity, host cells are incubated in the presence of serially diluted Atazanavir for 6 days and cell viability is quantitated using an XTT[2,3-bis(2-methoxy-4-nitro-5-sulfophenyl-2H-tetrazolium-5-carboxanilide] assay to calculate the 50% cytotoxic concentrations (CC50s). To assess the effect of human serum proteins on antiviral activity, the 10% fetal calf serum normally used for assays is replaced with 40% adult human serum or 1 mg of α1-acid glycoprotein/mL.(Only for Reference) Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Multidrug resistance protein 1, HIVProtease, HIV, HIV Protease, HIV protease, MDR1, Cytochrome P450, Cluster of differentiation 243, CD243, ABCB1, BMS 232632, BMS 232632 Sulfate, BMS232632, BMS232632 Sulfate, BMS-232632 sulfate, Atazanavir, P-glycoprotein, P-gp (P-glycoprotein), P-gp, Pgp, SARS-CoV, SARSCoV

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Compound Identifiers

PubChem CID

158550 ↗

Key Properties

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No computed properties available.

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