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ATC 0175

SKU: orb1704671

Description

ATC 0175 hydrochloride is a potent, selective, and orally active MCH1 receptor antagonist with additional affinity for 5-HT2B and 5-HT1A receptors. It demonstrates antidepressant and anxiolytic effects in animal models, making it a useful research tool for studying depression and anxiety disorders in both in vitro and in vivo experimental systems.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number510733-97-8
MW461.93
Purity99.98% (May vary between batches)
FormulaC23H26ClF2N5O
SMILESN(C)(C)C=1C2=C(N=C(N[C@H]3CC[C@@H](NC(=O)C4=CC(F)=C(F)C=C4)CC3)N1)C=CC=C2.Cl
TargetMelanin-concentrating Hormone Receptor (MCHR),5-HT Receptor,GPCR
SolubilityEthanol:22.5 mg/mL (48.71 mM);DMSO:9 mg/mL (19.48 mM)

Bioactivity

Target IC50
MCH1:13 nM|5-HT1A:16.9 nM|5-HT2B:9.66 nM
In Vivo
ATC0175 (1, 3, 10 mg/kg; p.o.) demonstrated antidepressant effects in the forced swimming test and exhibited anxiolytic effects across various animal models of anxiety, including the social interaction test, elevated plus-maze test, maternal separation-induced vocalization, and stress-induced hyperthermia.
In Vitro
In vitro, assays showed that this compound is a potent antagonist with a high affinity for MCH1R. The receptor binding and the functional assay (MCH-induced increase in [Ca2+]) indicated that ATC0175 is a noncompetitive antagonist at MCH1Rs.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

MCH1-R, MCHR1 (GPR24), MCHR, MCHR2, Melanin-concentrating Hormone Receptor, MelaninconcentratingHormoneReceptor(MCHR), MelaninconcentratingHormoneReceptor, Melaninconcentrating Hormone Receptor (MCHR), ATC 0175 hydrochloride, ATC 0175 Hydrochloride, ATC0175 Hydrochloride, ATC-0175 Hydrochloride, 5HTReceptor, 5HT Receptor, 5-HT1A, 5-HT2B

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  • ATC 0175 free base [orb1701156]

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Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

ATC 0175 (orb1704671)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 120.00
5 mg
$ 210.00
10 mg
$ 310.00
25 mg
$ 580.00
50 mg
$ 960.00
100 mg
$ 1,530.00
500 mg
$ 3,030.00
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