ATN-161 acetate

SKU: orb2665613

Description

ATN-161 acetate is a synthetic pentapeptide and non-competitive α5 integrin antagonist derived from fibronectin. It exhibits antitumor activity and has been shown in research to reduce pathology in caerulein-induced acute pancreatitis models, supporting its study in oncology and inflammation.

Research Area

Signal Transduction

Images & Validation

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Key Properties

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CAS Number	904763-58-2
MW	657.7
Purity	98.27%
Formula	C₂₅H₃₉N₉O₁₀S
SMILES	C(C)(O)=O.C(N[C@@H](CC1=CN=CN1)C(N[C@H](C(N[C@H](C(N[C@@H](CC(N)=O)C(N)=O)=O)CS)=O)CO)=O)(=O)[C@H]2N(C(C)=O)CCC2
Target	Integrin

Bioactivity

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In Vivo

Injection of ATN-161 acetate after laser photocoagulation reduced choroidal neovascularization (CNV) leakage and neovascularization with an inhibitory effect comparable to that of AF564.

In Vitro

The treatment regimen of ATN-161 acetate in combination with 5-FU was able to significantly inhibit the proliferation of tumor cells compared to control and monotherapy. In addition, the combination treatment significantly increased the proportion of TUNEL-positive tumor cells, while monotherapy failed to increase TUNEL-positive cells. ATN-161 acetate significantly reduced the number of cancer cells after 48 hours of culture (21% reduction) compared to the control group. ATN-161 acetate prevented vascular endothelial growth factor-induced migration and capillary formation of hCECs, but had no significant effect on proliferation. Starting at 100 nM, ATN-161 acetate decreased the number of cells migrating in response to VEGF in a dose-dependent manner (compared to the VEGF group).

Storage & Handling

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Storage	keep away from moisture,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Ac-PHSCN-NH2 acetate, ATN161 acetate, ATN-161 acetate(262438-43-7 Free base), ATN161acetate(262438437base)

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Compound Identifiers

PubChem CID

172652483 ↗

Key Properties

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No computed properties available.

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ATN-161 acetate (orb2665613)

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ATN-161 acetate

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

Quality Guarantee

Compound Identifiers

Key Properties

Documents Download

Request a Document

Protocol Information

ATN-161 acetate (orb2665613)

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