Aurantio-obtusin

SKU: orb1221888

Description

Biotransformation of glucoAurantio-obtusin towards Aurantio-obtusin increased the toxicity of irinotecan through increased inhibition of SN-38 glucuronidation. Aurantio-obtusin, stimulated chemotactic migration of MC3T3-E1 osteoblast cells in a concentration-dependent manner. Besides migration, the compound stimulated osteoblast differentiation and mineralization. Aurantio-obtusin is a promising osteoanabolic compound of natural origin with potential therapeutic applications in the prevention of osteoporosis and other metabolic bone diseases.

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Key Properties

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CAS Number	67979-25-3
MW	330.29
Purity	>98% (HPLC)
Formula	C₁₇H₁₄O₇
SMILES	CC1=C(C(=C2C(=C1)C(=O)C3=CC(=C(C(=C3C2=O)O)OC)O)OC)O
Target	Others
Solubility	In Vitro: DMSO : 25 mg/mL (75.69 mM)

Bioactivity

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In Vivo

Animal model: C57BL/6J mice model. Dosage: 5 mg/kg, 10 mg/kg, 15 mg/kg. Administration: Oral gavage (p.o.), feeding with HFSW diet for 4 weeks then giving different dose of Aurantio-obtusin for another 4 weeks. Result: Decreased the levels of TG and TC in liver and TG, ALT and AST in serum induced by HSFW. Reduced the number and size of fat droplets in liver cells. Significantly increased AMPK phosphorylation in HFSW-induced mice.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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