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AUZ 454

SKU: orb1300394

Description

AUZ 454

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number853299-07-7
MW501.5
Purity99.59%
FormulaC24H26F3N7O2
SMILESCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1
TargetCDK
SolubilityEthanol:12 mg/mL (23.93 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.58 mM);DMSO:245 mg/mL (488.53 mM);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
CDK2 (A144C):15.4 nM(Kd)|CDK2 (C118L):18.6 nM(Kd)|CDK2 (WT):50 nM(Kd)|CDK2 (C118L/A144C):9.7 nM(Kd)
In Vitro
K03861 inhibits CDK2 activity by competing with binding of activating cyclins.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CDK2, CDK2(A144C), CDK2(C118L), CDK2(C118L/A144C), CDK2(WT), CDK, cells, Cyclin dependent kinase, Caki-1, AUZ 454, AUZ454, AUZ-454, ACHN, inhibit, K 03861, K03861, K-03861, Inhibitor

Similar Products

  • K03861 [orb1223029]

    >98% (HPLC)

    853299-07-7

    501.5

    C24H26F3N7O2

    100 mg, 5 mg, 50 mg, 2 mg, 10 mg, 25 mg, 1 g, 500 mg, 200 mg
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Key Properties

No computed properties available.

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Protocol Information

AUZ 454 (orb1300394)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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5 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 100.00
10 mg
$ 110.00
25 mg
$ 190.00
50 mg
$ 270.00
100 mg
$ 400.00
200 mg
$ 540.00
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