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AV-412 free base

SKU: orb1678998

Description

AV-412 free base is a potent and selective small molecule inhibitor targeting EGFR and its common mutants, including T790M and L858R, with IC50 values in the low nanomolar range. It serves as a valuable research tool for investigating EGFR-driven oncogenesis in both cellular and animal models of non-small cell lung cancer and other malignancies.

Research Area

Cardiovascular Research, Signal Transduction

Images & Validation

Key Properties

CAS Number451492-95-8
MW507
FormulaC27H28ClFN6O
SMILESCN1CCN(CC1)C(C)(C)C#Cc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)C=C
TargetEGFR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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AV-412 free base (orb1678998)

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