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AZ7550

SKU: orb1708049

Description

AZ7550, the active metabolite of the third-generation EGFR inhibitor AZD9291 (Osimertinib), also functions as an IGF1R inhibitor with an IC50 of 1.6 µM. This compound is a valuable research tool for studying IGF1R signaling in cancer models, applicable in both in vitro biochemical assays and in vivo research exploring resistance mechanisms.

Research Area

Cardiovascular Research, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number1421373-99-0
MW485.58
Purity99.75%
FormulaC27H31N7O2
SMILESCN1C=C(C=2C1=CC=CC2)C3=NC(NC4=C(OC)C=C(N(CCNC)C)C(NC(C=C)=O)=C4)=NC=C3
TargetBTK,Tyrosine Kinases,FLT,FAK,IGF-1R,MNK,EGFR,PYK2,ACK1,Drug Metabolite,ALK,MLK
SolubilityDMSO:2.56 mg/mL (5.27 mM)

Bioactivity

Target IC50
BLK:977 nM |Brk:843 nM |Ack1:156 nM |FES:449 nM |FLT3:302 nM |FAK:995 nM |ALK:420 nM |MNK2:228 nM |PYK2:2288 nM |Insulin receptor:1256 nM |IRR:840 nM |TEC:1317 nM |ERB4:195 nM |FLT4:1784 nM |MLK1:88 nM |IGF-1R:1.6 μM
In Vitro
AZ7550 (Compound 28) inhibits double mutant (DM) cell line H1975, activating mutant (AM) cell line PC9, and wild type (WT) cell line LoVo (IC50s: 45, 26, and 786 nM). AZ7550 inhibits DM antiproliferative cell line H1975, AM antiproliferative cell line PC9, and WT antiproliferative cell line Calu3 (GI50s: 19, 15, and 537 nM).

Storage & Handling

Storagekeep away from moisture,store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ALK, ACK1, AZ7550, AZ-7550, BLK, BTK, AZ 7550, Drug Metabolite, DrugMetabolite, BRK, HER1, Ins R, INSR, IGF1R, IGF-1R, EGFR, Epidermal growth factor receptor, FAK, ErbB4, ErbB-1, FES, FLT4, FLT3, Inhibitor, IRR, inhibit, MNK2, MLK1, PYK2, Tyrosine Kinases, TyrosineKinases, Txk, TEC

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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AZ7550 (orb1708049)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 140.00
5 mg
$ 270.00
10 mg
$ 410.00
25 mg
$ 700.00
50 mg
$ 1,030.00
100 mg
$ 1,420.00
DispatchUsually dispatched within 3-5 working days
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