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Azadirachtin B

SKU: orb1707616

Description

Azadirachtin B (Deacetylazadirachtinol) is a bioactive terpenoid isolated from neem seeds. It exhibits insecticidal, anticancer, anti-inflammatory, and antiviral properties, making it a valuable research tool for studying viral infections and cancer biology in vitro. Studies also indicate it can promote osteoblast proliferation and differentiation.

Research Area

Infectious Disease & Virology, Metabolism Research

Images & Validation

Key Properties

CAS Number106500-25-8
MW662.68
Purity99.12%
FormulaC33H42O14
SMILESCC1([C@@]23[C@@](C)(O2)[C@]4(C[C@@]3(O[C@]5([C@]4(O)C=CO5)[H])[H])[H])[C@]6([C@@]7([C@]8([C@]([C@H]1O)(OC[C@]8(C(OC)=O)[C@H](OC(/C(=C/C)/C)=O)C[C@@H]7O)[H])[H])CO[C@@H]6C(OC)=O)[H]
TargetInfluenza Virus,Parasite,Phosphatase,Antifection
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.02 mM);DMSO:40 mg/mL (60.36 mM)

Bioactivity

In Vivo
Azadirachtin B (oral) has antitumor activity against peroxynitrite (ONOO-) -induced skin tumors in mice.
In Vitro
Azadirachtin B increases expression of RunX-2 ∼2.5 fold at 10 nM concentration, ALP expression ∼2.8 fold at 10 nM and 100 pM concentration and OCN expression ∼2.5 folds at 10 nM as compared with control. Azadirachtin B exhibits moderate or potent inhibitory effects (IC50 value of 384 mol ratio/32 pmol TPA) against the Epstein-Barr virus early antigen (EBV-EA) activation induced by tetradecanoylphorbol-13-acetate (TPA). Azadirachtin B exhibits toxicity to the diamondback moth (Plutella xylostella) with an LD50 of 4.85-1.06 µg/g body weight, in 92 h.

Storage & Handling

Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Azadirachtin B, Alkaline phosphatase (ALP), 3-Tigloylazadirachtol, Deacetylazadirachtinol, Plutella xylostella
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Azadirachtin B (orb1707616)

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% DMSO +
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% Tween 80 +
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Available Sizes

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1 mg
$ 170.00
5 mg
$ 590.00
10 mg
$ 940.00