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Azadiradione

SKU: orb1297018

Description

Azadiradione (AZD) is a limonoid isolated from the seeds of Azadirachta indica (neem). It is a research compound of interest in studies of inflammation and metabolic disorders, with demonstrated activity in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number26241-51-0
MW450.57
Purity99.91% (May vary between batches)
FormulaC28H34O5
SMILESC[C@]12C=3[C@](C)([C@@H](C(=O)C3)C=4C=COC4)CC[C@@]1([C@]5(C)[C@@](C[C@H]2OC(C)=O)(C(C)(C)C(=O)C=C5)[H])[H]
TargetOthers,HSP
SolubilityDMSO:55 mg/mL (122.07 mM)

Bioactivity

In Vitro
Azadiradione (AZD) ameliorates toxicity due to protein aggregation in cell and fly models of polyglutamine expansion diseases to a great extent. All these effects are correlated with activation of HSF1 function and expression of its target protein chaperone genes. Notably, HSF1 activation by AZD is independent of cellular HSP90 or proteasome function. Furthermore, we show that AZD directly interacts with purified human HSF1 with high specificity, and facilitates binding of HSF1 to its recognition sequence with higher affinity. These unique findings qualify AZD as an ideal lead molecule for consideration for drug development against NDs that affect millions worldwide.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

bioactive limonoid, Azadiradione, anti-nociceptive, anti-inflammatory activities, antimycobacterial, AZD, inhibit, Inhibitor, Heat shock proteins, HSF1 Activator, HSP

Similar Products

  • Azadiradione [orb1218251]

    >98% (HPLC)

    26241-51-0

    450.57

    C28H34O5

    200 mg, 10 mg, 25 mg, 50 mg, 100 mg, 5 mg, 1 g, 500 mg
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Key Properties

No computed properties available.

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Azadiradione (orb1297018)

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% DMSO +
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% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 180.00
5 mg
$ 350.00
1 ml x 10 mM (in DMSO)
$ 420.00
10 mg
$ 590.00
25 mg
$ 860.00
50 mg
$ 1,170.00
100 mg
$ 1,570.00
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